Kevin Whaley has worked for the last 30 years on the development of MPTs to prevent sexually transmitted diseases and unintended pregnancy. He co-founded Mapp Biopharmaceutical to develop antibody-based MPTs, therapeutics and mucosal vaccines that are appropriate for large, cost-sensitive, global health markets.
Monoclonal antibodies are engineered proteins derived from a single parent cell and have been used in a diverse range of therapeutic applications due to their versatility and specificity. At Mapp Biopharmaceutical, Inc., we believe monoclonal antibodies are promising candidates for multipurpose prevention technologies (MPTs) when formulated as topical (e.g., films and rings) or injectable products. Systemic antibodies may have multiple effector functions – like complement binding (CDC) and binding to monocytes (ADCC) – while mucosal mechanisms agglutination and trapping in mucus are less widely discussed, but are crucial for the protection of mucosal surfaces. Systemically and mucosally delivered antibodies have demonstrated efficacy in SHIV prevention studies. In this post, we describe some of the important progress to date on monoclonal antibodies as future MPTs.
This project is made possible by the generous support of the American people through the United States Agency for International Development (USAID) under the terms of Cooperative Agreement #AID-OAA-A-16-00045. The contents are the responsibility of the IMPT, CAMI Health, PHI, and its partners and do not necessarily reflect the views of USAID or the U.S. Government.